Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients

Silva Rodrigues, Tamara; Santos Guedes de Sá, Keyla; Y. Ishimoto, Adriene; Becerra, Amanda; Oliveira, Samuel; de Almeida, Letícia; V. Gonçalves, Augusto; B. Perucello, Debora; A. Andrade, Warrison; Cardoso Castro, Ricardo; P. Veras, Flávio; E. Toller-Kawahisa, Juliana; C. Nascimento, Daniele; Haruo Fernandes de Lima, Mikhael; M. Silva, Camila; B. Caetité, Diego; B. Martins, Ronaldo; A. Castro, Ítalo; Cornejo Pontelli, Marjorie; Cury de Barros, Fábio; B. do Amaral, Natália; C Giannini, Marcela; Pastorelli Bonjorno, Letícia; Isabel Fernandes Lopes, Maria; de Carvalho Santana, Rodrigo; Crivelenti Vilar, Fernando; Auxiliadora‐Martins, Maria; Luppino Assad, Rodrigo; C. L. Almeida, Sérgio; Reis de Oliveira, Fabíola; Setembre Batah, Sabrina; Siyuan, Li; Nilson Benatti, Maíra; M. Cunha, Thiago; C. Alves‐Filho, José; Q. Cunha, Fernando; D. Cunha, Larissa; Gai Frantz, Fabiani; Kohlsdorf, Tiana; Todorovic Fabro, Alexandre; Arruda, Eurico; Donizeti Ribeiro de Oliveira, Renê; Louzada‐Júnior, Paulo; S. Zamboni, Dario

doi:10.1084/jem.20201707

Public

Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients

Published in The Journal of Experimental Medicine • Nov 11, 2020

Authors:

Tamara Silva Rodrigues

Keyla Santos Guedes de Sá

Adriene Y. Ishimoto

Abstract

Severe cases of COVID-19 are characterized by a strong inflammatory process that may ultimately lead to organ failure and patient death. The NLRP3 inflammasome is a molecular platform that promotes inflammation via cleavage and activation of key inflammatory molecules including active caspase-1 (Cas...

Subject

Inflammasome

Coronavirus disease 2019 (COVID-19)

Inflammation

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