Melatonin Suppresses Ferroptosis Induced by High Glucose via Activation of the Nrf2/HO-1 Signaling Pathway in Type 2 Diabetic Osteoporosis

Ma, Hongdong; Wang, Xindong; Zhang, Weilin; Li, Haitian; Zhao, Wei; Sun, Jun; Yang, Maowei

doi:10.1155/2020/9067610

Public

Melatonin Suppresses Ferroptosis Induced by High Glucose via Activation of the Nrf2/HO-1 Signaling Pathway in Type 2 Diabetic Osteoporosis

Published in Oxidative Medicine and Cellular Longevity • Dec 4, 2020

Authors:

Hongdong Ma

Xindong Wang

Weilin Zhang

Abstract

Ferroptosis is recently identified, an iron- and reactive oxygen species- (ROS-) dependent form of regulated cell death. This study was designed to determine the existence of ferroptosis in the pathogenesis of type 2 diabetic osteoporosis and confirm that melatonin can inhibit the ferroptosis of ost...

Subject

Osteoblast

Osteopontin

Chemistry

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