Pembrolizumab in Microsatellite-Instability–High Advanced Colorectal Cancer

André, Thierry; Shiu, Kai‐Keen; Won Kim, Tae; Vittrup Jensen, Benny; Henrik Jensen, Lars; J.A. Punt, Cornelis; Smith, Denis; García‐Carbonero, Rocio; Benavides, Manuel; Gibbs, Peter; de la Fouchardière, Christelle; Rivera, Fernando; Élez, Elena; C. Bendell, Johanna; T. Le, Dung; Yoshino, Takayuki; Van Cutsem, Eric; Yang, Ping; Z.H. Farooqui, Mohammed; Marinello, Patricia; A. Díaz, Luis

doi:10.1056/nejmoa2017699

Public

Pembrolizumab in Microsatellite-Instability–High Advanced Colorectal Cancer

Published in New England Journal of Medicine • Dec 2, 2020

Authors:

Thierry André

Kai‐Keen Shiu

Tae Won Kim

Abstract

BACKGROUND: Programmed death 1 (PD-1) blockade has clinical benefit in microsatellite-instability-high (MSI-H) or mismatch-repair-deficient (dMMR) tumors after previous therapy. The efficacy of PD-1 blockade as compared with chemotherapy as first-line therapy for MSI-H-dMMR advanced or metastatic co...

Subject

Microsatellite instability

Pembrolizumab

Colorectal cancer

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