Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19

F. Bermejo-Martin, Jesús; González-Rivera, Milagros; Almansa, Raquel; Micheloud, Dariela; P. Tedim, Ana; Domínguez-Gil, Marta; Resino, Salvador; Martín-Fernández, Marta; Ryan Murua, Pablo; Pérez-García, Felipe; Tamayo, Luis; Lopez-Izquierdo, Raúl; Bustamante, Elena; Aldecoa, César; Manuel Gómez, José; Rico-Feijoo, Jesús; Orduña, Antonio; Méndez, Raúl; Fernández Natal, Isabel; Megías, Gregoria; González-Estecha, Montserrat; Carriedo, Demetrio; Doncel, Cristina; Jorge, Noelia; Ortega, Alicia; de la Fuente, Amanda; del Campo, Félix; Antonio Fernández-Ratero, José; Trapiello, Wysali; González-Jiménez, Paula; Ruiz, Guadalupe; A. Kelvin, Alyson; Toloue Ostadgavahi, Ali; Oneizat, Ruth; María Ruiz, Luz; Miguéns, Iria; Gargallo, Esther; Muñoz, Ioana; Pelegrin, Sara; Martín, Silvia; García Olivares, Pablo; Antonio Cedeño, Jamil; Ruiz Albi, Tomás; Puertas, Carolina; Ángel Berezo, Jose; Renedo, Gloria; Herrán, Rubén; Bustamante-Munguira, Juan; Enríquez, Pedro; Cicuendez, Ramón; Blanco, Jesús; Abadia, Jesica; Gómez Barquero, Julia; Mamolar, Nuria; Blanca-López, Natalia; Jorge Valdivia, Luis; Fernández Caso, Belén; Ángeles Mantecón, María; Motos, Anna; Fernandez-Barat, Laia; Ferrer, Ricard; Barbé, Ferrán; Torres, Antoni; Menéndez, Rosario; María Eiros, José; J. Kelvin, David

doi:10.1186/s13054-020-03398-0

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Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19

Shared by NobleBlocks on Dec 1, 2020 • 12:00 AM UTC

Authors:

Jesús F. Bermejo-Martin

Milagros González-Rivera

Raquel Almansa

Abstract

Abstract Background COVID-19 can course with respiratory and extrapulmonary disease. SARS-CoV-2 RNA is detected in respiratory samples but also in blood, stool and urine. Severe COVID-19 is characterized by a dysregulated host response to this virus. We studied whether viral RNAemia or viral RNA loa...

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