Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer

Krishna, Sri; J. Lowery, Frank; R. Copeland, Amy; Bahadiroglu, Erol; Mukherjee, Ratnadeep; Jia, Li; Anibal, James; Sachs, Abraham; Adebola, Serifat; Gurusamy, Devikala; Yu, Zhiya; Hill, Victoria; J. Gartner, Jared; F. Li, Yong; R. Parkhurst, Maria; C. Paria, Biman; Kvistborg, Pia; C. Kelly, Michael; L. Goff, Stephanie; Altan‐Bonnet, Grégoire; F. Robbins, Paul; A. Rosenberg, Steven

doi:10.1126/science.abb9847

Public

Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer

Published in Science • Dec 10, 2020

Authors:

Sri Krishna

Frank J. Lowery

Amy R. Copeland

Abstract

Stem-like T cells mediate response Adoptive cell transfer (ACT) is a type of immunotherapy that uses a patient's own T lymphocytes to recognize and attack cancer. ACT has been effective in treating certain patients with metastatic melanoma and is being applied to treat some epithelial cancers. Krish...

Subject

Adoptive cell transfer

Adoptive immunotherapy

CD8

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