H3K27 acetylation activated-COL6A1 promotes osteosarcoma lung metastasis by repressing STAT1 and activating pulmonary cancer-associated fibroblasts

Zhang, Ying; Liu, Zhaoyong; Yang, Xia; Lu, Weiqing; Chen, Yelong; Lin, Youbin; Wang, Jin; Lin, Suxia; Yun, Jing‐Ping

doi:10.7150/thno.51245

Public

H3K27 acetylation activated-COL6A1 promotes osteosarcoma lung metastasis by repressing STAT1 and activating pulmonary cancer-associated fibroblasts

Published in Theranostics • Dec 16, 2020

Authors:

Ying Zhang

Zhaoyong Liu

Xia Yang

Abstract

Our data demonstrated that upregulation of COL6A1 activated by H3K27 acetylation promoted the cell migration and invasion by suppressing STAT1 pathway in OS cells. Moreover, COL6A1 can be packaged into OS cell-derived exosomes and activate CAFs to promote OS metastasis.

Subject

Cancer research

Chromatin immunoprecipitation

Chemistry

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