Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Voysey, Merryn; Ann Costa Clemens, Sue; A. Madhi, Shabir; Yin Weckx, Lily; M. Folegatti, Pedro; K. Aley, Parvinder; Angus, Brian; L. Baillie, Vicky; Barnabas, Shaun; Bhorat, Qasim; Bibi, Sagida; Briner, Carmen; Cicconi, Paola; M. Collins, Andrea; Colin-Jones, Rachel; Cutland, Clare; C. Darton, Thomas; Dheda, Keertan; Duncan, C.J.; R. W. Emary, Katherine; Ewer, Katie; Fairlie, Lee; N. Faust, Saul; Feng, Shuo; M. Ferreira, Daniela; Finn, Adam; L. Goodman, Anna; Green, Catherine; Green, Christopher; T. Heath, Paul; Hill, Catherine; Hill, Helen; Hirsch, Ian; H. Hodgson, Susanne; Izu, Alane; Jackson, Susan; Jenkin, Daniel; C. D. Joe, Carina; Kerridge, Simon; Koen, Anthonet; Kwatra, Gaurav; Lazarus, Rajeka; M. Lawrie, Alison; Lelliott, Alice; Libri, Vincenzo; Lillie, Patrick; M. Mallory, Raburn; Verena Almeida Mendes, Ana; Pı́polo Milan, Eveline; M. Minassian, Angela; McGregor, Alastair; Morrison, Hazel; F Mujadidi, Yama; Nana, Anusha; O’Reilly, Peter; D. Padayachee, Sherman; Maria Pittella, Ana; Plested, Emma; M. Pollock, Katrina; Ramasamy, Maheshi; Rhead, Sarah; Vargas Schwarzbold, Alexandre; Singh, Nisha; Smith, Darren; Song, Rinn; D. Snape, Matthew; Sprinz, Eduardo; Sutherland, Rebecca; Tarrant, Richard; C. Thomson, Emma; Estée Török, M.; Toshner, Mark; P. J. Turner, David; Vekemans, Johan; Villafana, Tonya; Watson, Marion; J. Williams, Christopher; D. Douglas, Alexander; V. S. Hill, Adrian; Lambe, Teresa; C. Gilbert, Sarah; J. Pollard, Andrew; Aban, Marites; Abayomi, Fatola; W.M. Abeyskera, Kushala; Aboagye, Jeremy; Adam, Matthew; Adams, Kirsty; P. Adamson, James; Adelaja, Yemi; Adewetan, Gbadebo; Adlou, Syed; Ahmed, Khatija; Akhalwaya, Yasmeen; Akhalwaya, Saajida; Alcock, Andrew; Ali, Aabidah; Allen, Elizabeth; Allen, Lauren; C. D. S. C Almeida, Thamires; Alves, Mariana; Ferreira Amorim, Fábio; Andritsou, Foteini; Anslow, Rachel; Appleby, Matthew; H. Arbe-Barnes, Edward; P. 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doi:10.1016/s0140-6736(20)32661-1

Public

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Published in The Lancet • Dec 8, 2020

Authors:

Merryn Voysey

Sue Ann Costa Clemens

Shabir A. Madhi

Abstract

Background A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis o...

Subject

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Coronavirus disease 2019 (COVID-19)

2019-20 coronavirus outbreak

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