Uric Acid as a Risk Factor for Chronic Kidney Disease and Cardiovascular Disease　― Japanese Guideline on the Management of Asymptomatic Hyperuricemia ―

Hisatome, Ichiro; Li, Peili; Miake, Junichiro; Taufiq, Fikri; Mahati, Endang; Maharani, Nani; Bayu Utami, Sulistiyati; Kuwabara, Masanari; Bahrudin, Udin; Ninomiya, Haruaki

doi:10.1253/circj.cj-20-0406

Public

Uric Acid as a Risk Factor for Chronic Kidney Disease and Cardiovascular Disease ― Japanese Guideline on the Management of Asymptomatic Hyperuricemia ―

Published in Circulation Journal • Dec 17, 2020

Authors:

Ichiro Hisatome

Peili Li

Junichiro Miake

Abstract

Serum uric acid (UA) is taken up by endothelial cells and reduces the level of nitric oxide (NO) by inhibiting its production and accelerating its degradation. Cytosolic and plasma xanthine oxidase (XO) generates superoxide and also decreases the NO level. Thus, hyperuricemia is associated with impa...

Subject

Hyperuricemia

Medicine

Febuxostat

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