Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

N. Baruch, Erez; Youngster, Ilan; Ben‐Betzalel, Guy; Ortenberg, Rona; Lahat, Adi; H. Katz, Lior; Adler, Katerina; Dick‐Necula, Daniela; Raskin, Stephen; Bloch, Naamah; Л. Ротин, Д.; Anafi, Liat; Avivi, Camila; Melnichenko, Jenny; Steinberg‐Silman, Yael; Mamtani, Ronac; Harati, Hagit; Asher, Nethanel; Shapira‐Frommer, Ronnie; Brosh‐Nissimov, Tal; Eshet, Yael; Ben-Simon, Shira; Oren, Ziv; Abdul Wadud Khan, Md; Amit, Moran; J. Ajami, Nadim; Barshack, Iris; Schachter, Jacob; A. Wargo, Jennifer; Koren, Omry; Markel, Gal; Boursi, Ben

doi:10.1126/science.abb5920

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Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

Published in Science • Dec 10, 2020

Authors:

Erez N. Baruch

Ilan Youngster

Guy Ben‐Betzalel

Abstract

The gut microbiome has been shown to influence the response of tumors to anti-PD-1 (programmed cell death-1) immunotherapy in preclinical mouse models and observational patient cohorts. However, modulation of gut microbiota in cancer patients has not been investigated in clinical trials. In this stu...

Subject

Fecal bacteriotherapy

Refractory (planetary science)

Immunotherapy

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