Genetic mechanisms of critical illness in COVID-19

GenOMICC Investigators, The; Pairo‐Castineira, Erola; ISARIC4C Investigators, The; COVID-19 Human Genetics Initiative, The; Investigators, 23andMe; Investigators, BRACOVID; Investigators, Gen-COVID; Clohisey, Sara; Klarić, Lucija; D. Bretherick, Andrew; Rawlik, Konrad; Pasko, Dorota; Walker, Susan; Parkinson, Nick; Head Fourman, Max; D Russell, Clark; Furniss, James; Richmond, Anne; Gountouna, Viktoria‐Eleni; Wrobel, Nicola; A Harrison, David; Wang, Bo; Wu, Yang; Meynert, Alison; Griffiths, Fiona; Oosthuyzen, Wilna; Kousathanas, Athanasios; Moutsianas, Loukas; Yang, Zhijian; Zhai, Ranran; Zheng, Chenqing; R. Grimes, Graeme; Beale, Rupert; Millar, Jonathan; Shih, Barbara; Keating, Seán; Zechner, Marie; Haley, Chris; J. Porteous, David; Hayward, Caroline; Yang, Jian; C. Knight, Julian; Summers, Charlotte; Shankar‐Hari, Manu; Klenerman, Paul; Turtle, Lance; Ho, Antonia; C. Moore, Shona; Hinds, Charles; Horby, Peter; Nichol, Alistair; M. Maslove, David; Ling, Lowell; McAuley, Danny; Montgomery, Hugh; Walsh, Timothy; C. Pereira, Alexandre; Renieri, Alessandra; Shen, Xia; P. Ponting, Chris; Fawkes, Angie; Tenesa, Albert; J. Caulfield, Mark; H. Scott, Richard; Rowan, Kathy; Murphy, Lee; Openshaw, Peter; G. Semple, Malcolm; Law, Andrew; Vitart, Véronique; F. Wilson, James; Kenneth Baillie, J.; Kenneth Baillie, J.

doi:10.1038/s41586-020-03065-y

Public

Genetic mechanisms of critical illness in COVID-19

Published in Nature • Dec 11, 2020

Authors:

The GenOMICC Investigators

Erola Pairo‐Castineira

The ISARIC4C Investigators

Abstract

Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC ...

Subject

Biology

Genome-wide association study

Genetics

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