IgA dominates the early neutralizing antibody response to SARS-CoV-2

Sterlin, Delphine; Mathian, Alexis; Miyara, Makoto; Mohr, Audrey; Anna, François; Claër, Laetitia; Quentric, Paul; Fadlallah, Jehane; Devilliers, Hervé; Ghillani, P.; Gunn, Cary; Hockett, Rick; Mudumba, Sasi; Guihot, Amélie; Luyt, Charles‐Édouard; Mayaux, Julien; Beurton, Alexandra; Fourati, S.; Bruel, Timothée; Schwartz, Olivier; Lacorte, Jean‐Marc; Yssel, Hans; Parizot, Christophe; Dorgham, Karim; Charneau, Pierre; Amoura, Zahir; Gorochov, Guy

doi:10.1126/scitranslmed.abd2223

Public

IgA dominates the early neutralizing antibody response to SARS-CoV-2

Published in Science Translational Medicine • Dec 7, 2020

Authors:

Delphine Sterlin

Alexis Mathian

Makoto Miyara

Abstract

Humoral immune responses are typically characterized by primary IgM antibody responses followed by secondary antibody responses associated with immune memory and composed of IgG, IgA, and IgE. Here, we measured acute humoral responses to SARS-CoV-2, including the frequency of antibody-secreting cell...

Subject

Neutralizing antibody

Antibody response

Antibody

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