Clinical and Genetic Tumor Characteristics of Responding and Non-Responding Patients to PD-1 Inhibition in Hepatocellular Carcinoma

Spahn, Stephan; Roessler, Daniel; Pompilia, Radu; Gabernet, Gisela; Primrose Gladstone, Beryl; Horger, Marius; Biskup, Saskia; Feldhahn, Magdalena; Nahnsen, Sven; J. Hilke, Franz; Scheiner, Bernhard; Dufour, Jean‐François; N. De Toni, Enrico; Pinter, Matthias; P. Malek, Nisar; Bitzer, Michael

doi:10.3390/cancers12123830

Public

Clinical and Genetic Tumor Characteristics of Responding and Non-Responding Patients to PD-1 Inhibition in Hepatocellular Carcinoma

Published in Cancers • Dec 18, 2020

Authors:

Stephan Spahn

Daniel Roessler

Radu Pompilia

Abstract

Immune checkpoint inhibitors (ICIs) belong to the therapeutic armamentarium in advanced hepatocellular carcinoma (HCC). However, only a minority of patients benefit from immunotherapy. Therefore, we aimed to identify indicators of therapy response. This multicenter analysis included 99 HCC patients....

Subject

Hepatocellular carcinoma

Medicine

Internal medicine

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