The role of polygenic risk and susceptibility genes in breast cancer over the course of life

Mars, Nina; Widén, Elisabeth; Kerminen, Sini; J Meretoja, Tuomo; Pirinen, Matti; Della Briotta Parolo, Pietro; Palta, Priit; , FinnGen; S. Havulinna, Aki; Elliott, Amanda; Shcherban, Anastasia; Ganna, Andrea; Jalanko, Anu; Lehistö, Arto; Kilpeläinen, Elina; Brein, Georg; Ghazal, Awaisa; Laivuori, Hannele; Heyne, Henrike; Harju, Jarmo; Lee, Jiwoo; Karjalainen, Juha; Koskela, Jukka; Pärn, Kalle; Donner, Kati; Tsuo, Kristin; González Jiménez, Manuel; Kaunisto, Mari; Niemi, Mari; Pat Reeve, Mary; Aavikko, Mervi; Kurki, Mitja; Alexander Dada, Oluwaseun; Della Briotta Parolo, Pietro; Kajanne, Risto; Rüeger, Sina; Lemmelä, Susanna; Tukiainen, Taru; Tuomi, Tiinamaija; P. Sipilä, Timo; Kiiskinen, Tuomo; Llorens, Vincent; Ziemann, Adam; Lehtonen, Anne; Lertratanakul, Apinya; Georgantas, Bob; Riley‐Gillis, Bridget; Quarless, Danjuma; Rahimov, Fedik; J. Jacob, Howard; F. Waring, Jeffrey; Wade Davis, J.; Smaoui, Nizar; Popovic, Relja; Esmaeeli, Sahar; Matakidou, Athena; Challis, Ben; A. Close, David; Wigmore, Eleonor; Petrovski, Slavé; Chen, Chia‐Yen; Tsai, Ellen; Runz, Heiko; Z. Liu, Jimmy; G. Bronson, Paola; John, Sally; Lahdenperä, Sanni; Loomis, Stephanie; Eaton, Susan; Huang, Yunfeng; Kvikstad, Erika; Çalışkan, Minal; Wadhawan, Samir; Shaikho Elhaj Mohammed, Elmutaz; van Adelsberg, Janet; Maranville, Joseph; Hochfeld, Marla; M. Plenge, Robert; Biswas, Shameek; M. Greenberg, Steven; S. Peterson, Andrew; F. Choy, David; Chang, Diana; Teng, Edmond; C. Strauss, Erich; Kerchner, Geoff; Chen, Hao; Chen, Hubert; L. Schutzman, Jennifer; A. Michon, John; Hunkapiller, Julie; I. McCarthy, Mark; Bowers, Natalie; A. Pendergrass, Sarah; Bhangale, Tushar; Pulford, David; Waterworth, Dawn; Kulkarni, Diptee; Xu, Fanli; Betts, Jo; Esparza Gordillo, Jorge; Hoffman, Joshua; S. King, Karen; Ehm, Meg; Ghosh, Soumitra; Loerch, Patrick; Fleuren, Wilco; B. Cummings, Beryl; Brauer, Matt; Graham, Robert; Behrens, Tim; Loboda, Andrey; Podgornaia, Anna; Chhibber, Aparna; Y. Chu, Audrey; S. Fox, Caroline; Diogo, Dorothée; Holzinger, Emily; D. Eicher, John; Gormley, Padhraig; Mehta, Vinay; Mälarstig, Anders; K. Hedman, Åsa; Marshall, Catherine; D. Whelan, Christopher; Lehtonen, Heli; Parkkinen, Jaakko; Linden, Kari; Kalpala, Kirsi; Miller, Melissa; Bing, Nan; McDonough, Stefan; Chen, Xing; Hu, Xinli; Wu, Ying; J. Muslin, Anthony; Wang, Clarence; Chatelain, Clément; K. Rajpal, Deepak; Liu, Dongyu; Xu, Ethan; Augé, Franck; M. Call, Katherine; Klinger, Kathy; Crohns, Marika; Gossel, Matthias; Xia, Tai-he; Hendolin, Minna; Tuovila, Outi; Tuovila, Outi; Pakkanen, Raimo; Karlsson, Antti; Pulkki, Kari; Kallio, Lila; Virolainen, Petri; Mannermaa, Arto; Heikkinen, Sami; Kosma, Veli‐Matti; K. Laakkonen, Eija; Laukkanen, Jari; Kuopio, Teijo; M. Kujala, Urho; Kangasniemi, Eeva; Mäkelä, Johanna; Ritari, Jarmo; Partanen, Jukka; Hyvärinen, Kati; Arvas, Mikko; Pitkäranta, Anne; Loukola, Anu; Punkka, Eero; Koskinen, Miika; Carpén, Olli; Salminen, Aino; Rice, David; Mattson, Johanna; A. Turunen, Joni; Sinisalo, Juha; Hannula‐Jouppi, Katariina; A. Aaltonen, Lauri; Taskinen, Marja‐Riitta; Färkkilâ, Martti; Kauppi, Paula; Nieminen, Pekka; Tienari, Pentti; J. Pussinen, Pirkko; Pikkarainen, Sampsa; Seitsonen, Sanna; Ollila, Terhi; Tuomi, Tiinamaija; Salo, Tuula; Palotie, Ulla; O. Rinne, Juha; Metsärinne, Kaj; Elenius, Klaus; Koulu, Leena; Voutilainen, Markku; Juonala, Markus; Peltonen, Sirkku; Kahraman Gürsoy, Ulvi; Aaltonen, Vesa; Kettunen, Johannes; Pylkäs, Katri; Kalaoja, Marita; Turpeinen, Miia; K. Karjalainen, Minna; Serpi, Raisa; Hinttala, Reetta; Kaarteenaho, Riitta; Vainio, Seppo; Mantere, Tuomo; M. Remes, Anne; Junttila, Juhani; Tasanen, Kaisa; Sipilä, Kirsi; Huilaja, Laura; Luodonpää, Marja; Hautala, Nina; Karihtala, Peeter; Kauppila, Saila; Harju, Terttu; Blomster, Timo; Anttonen, Vuokko; Soininen, Hilkka; T. Harvima, Ilkka; Pihlajamäki, Jussi; Kaarniranta, Kai; Suominen, Liisa; Pelkonen, Margit; Siponen, Maria; Laakso, Markku; Hiltunen, Mikko; Kiviniemi, Mikko; Auvinen, Päivi; Mäntylä, Päivi; Kälviäinen, Reetta; Julkunen, Valtteri; Auranen, Annika; Jussila, Airi; Uusitalo‐Järvinen, Hannele; Kankaanranta, Hannu; Uusitalo, Hannu; Peltola, Jukka; Kähönen, Mika; Laitinen, Tarja; Salmi, Teea; Järvensivu, Elina; Kaiharju, Essi; Mattsson, Hannele; Kristiansson, Kati; Männikkö, Lotta; Laukkanen, Markku; Perola, Markus; Laiho, Päivi; Wong, Regis; Lähteenmäki, Sini; Soini, Sirpa; Niiranen, Teemu; Paajanen, Teemu; Kilpi, Terhi; Hiekkalinna, Tero; Sistonen, Tuuli; Salomaa, Veikko; Kanai, Masahiro; Zhou, Wei; P. Mäkelä, Tomi; Rivas, Manuel; Palin, Kimmo; Siirtola, Harri; Gracia‐Tabuenca, Javier; Sipeky, Csilla; Jambulingam, Dhanaprakash; Schleutker, Johanna; Heron, Samuel; Subramaniam Rathinakannan, Venkat; Palotie, Aarno; Kaprio, Jaakko; Joensuu, Heikki; J. Daly, Mark; Ripatti, Samuli

doi:10.1038/s41467-020-19966-5

Public

The role of polygenic risk and susceptibility genes in breast cancer over the course of life

Published in Nature Communications • Dec 14, 2020

Authors:

Nina Mars

Elisabeth Widén

Sini Kerminen

Abstract

Abstract Polygenic risk scores (PRS) for breast cancer have potential to improve risk prediction, but there is limited information on their utility in various clinical situations. Here we show that among 122,978 women in the FinnGen study with 8401 breast cancer cases, the PRS modifies the breast ca...

Subject

Breast cancer

PALB2

Medicine

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