[11C]MODAG-001—towards a PET tracer targeting α-synuclein aggregates

Kuebler, Laura; Buss, Sabrina; Leonov, Andrei; Ryazanov, Sergey; Schmidt, Felix; Maurer, Andreas; Weckbecker, Daniel; M. Landau, Anne; P. Lillethorup, Thea; Bleher, Daniel; Sing Saw, Ran; J. Pichler, Bernd; Griesinger, Christian; Giese, Armin; Herfert, Kristina

doi:10.1007/s00259-020-05133-x

Public

[11C]MODAG-001—towards a PET tracer targeting α-synuclein aggregates

Published in European Journal of Nuclear Medicine and Molecular Imaging • Dec 28, 2020

Authors:

Laura Kuebler

Sabrina Buss

Andrei Leonov

Abstract

Abstract Purpose Deposition of misfolded alpha-synuclein (αSYN) aggregates in the human brain is one of the major hallmarks of synucleinopathies. However, a target-specific tracer to detect pathological aggregates of αSYN remains lacking. Here, we report the development of a positron emission tomogr...

Subject

Fibril

In vivo

Dementia with Lewy bodies

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