Increase in <i>Kelch 13</i> Polymorphisms in <i>Plasmodium falciparum</i>, Southern Rwanda

Bergmann, Clara; van Loon, Welmoed; Habarugira, Felix; Tacoli, Costanza; C. Jäger, Julia; Savelsberg, Darius; Nshimiyimana, Fabian; Rwamugema, Elias; Mbarushimana, Djibril; Ndoli, Jules; Sendegeya, Augustin; Bayingana, Claude; P. Mockenhaupt, Frank

doi:10.3201/eid2701.203527

Public

Increase in Kelch 13 Polymorphisms in Plasmodium falciparum, Southern Rwanda

Published in Emerging infectious diseases • Dec 21, 2020

Authors:

Clara Bergmann

Welmoed van Loon

Felix Habarugira

Abstract

Artemisinin resistance in Plasmodium falciparum is associated with nonsynonymous mutations in the Kelch 13 (K13) propeller domain. We found that 12.1% (8/66) of clinical P. falciparum isolates from Huye district, Rwanda, exhibited K13 mutations, including R561H, a validated resistance marker. K13 mu...

Subject

Plasmodium falciparum

Nonsynonymous substitution

Biology

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