The SARS-CoV-2 RNA–protein interactome in infected human cells

Schmidt, Nora; A. Lareau, Caleb; Keshishian, Hasmik; Ganskih, Sabina; Schneider, Cornelius; Hennig, Thomas; Melanson, Randy; Werner, Simone; Wei, Yuanjie; M. Zimmer, Matthias; Ade, Jens; Kirschner, Luisa; Zielinski, Sebastian; Dölken, Lars; S. Lander, Eric; Caliskan, Neva; Fischer, Utz; Vogel, Jörg; A. Carr, Steven; Bodem, Jochen; Munschauer, Mathias

doi:10.1038/s41564-020-00846-z

Public

The SARS-CoV-2 RNA–protein interactome in infected human cells

Published in Nature Microbiology • Dec 21, 2020

Authors:

Nora Schmidt

Caleb A. Lareau

Hasmik Keshishian

Abstract

Characterizing the interactions that SARS-CoV-2 viral RNAs make with host cell proteins during infection can improve our understanding of viral RNA functions and the host innate immune response. Using RNA antisense purification and mass spectrometry, we identified up to 104 human proteins that direc...

Subject

Interactome

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Virology

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