Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss

Nakao, Yuki; Fukuda, Takao; Zhang, Qunzhou; Sanui, Terukazu; Shinjo, Takanori; Kou, Xiaoxing; Chen, Chider; Liu, Dawei; Watanabe, Yukari; Hayashi, Chikako; Yamato, Hiroaki; Yotsumoto, Karen; Tanaka, Urara; Taketomi, Takaharu; Uchiumi, Takeshi; D. Le, Anh; Shi, Songtao; Nishimura, Fusanori

doi:10.1016/j.actbio.2020.12.046

Public

Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss

Published in Acta Biomaterialia • Dec 24, 2020

Authors:

Yuki Nakao

Takao Fukuda

Qunzhou Zhang

Abstract

Mesenchymal stem cell (MSC)-derived exosome plays a central role in the cell-free therapeutics involving MSCs and the contents can be customized under disease-associated microenvironments. However, optimal MSC-preconditioning to enhance its therapeutic potential is largely unknown. Here, we show tha...

Subject

Microvesicles

Mesenchymal stem cell

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