Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

V. Conti, David; F. Darst, Burcu; C. Moss, Lilit; J. Saunders, Edward; Sheng, Xin; Chou, Alisha; R. Schumacher, Fredrick; Amin Al Olama, Ali; Benlloch, Sara; Dadaev, Tokhir; N. Brook, Mark; Sahimi, Ali; J. Hoffmann, Thomas; Takahashi, Atushi; Matsuda, Koichi; Momozawa, Yukihide; Fujita, Masashi; Muir, Kenneth; Lophatananon, Artitaya; Wan, Peggy; Le Marchand, Loı̈c; R. Wilkens, Lynne; L. Stevens, Victoria; M. Gapstur, Susan; D. Carter, Brian; Schleutker, Johanna; L.J. Tammela, Teuvo; Sipeky, Csilla; Auvinen, Anssi; G. Giles, Graham; C. Southey, Melissa; J. MacInnis, Robert; Cybulski, Cezary; Wokołorczyk, Dominika; Lubiński, Jan; E. Neal, David; L. Donovan, Jenny; C. Hamdy, Freddie; M. Martin, Richard; G. Nordestgaard, Børge; F. Nielsen, Sune; Weischer, Maren; E. Bojesen, Stig; Andreas Røder, Martin; Iversen, Peter; Batra, Jyotsna; K. Chambers, Suzanne; Moya, Leire; G. Horvath, Lisa; A. Clements, Judith; D. Tilley, Wayne; P. Risbridger, Gail; Grönberg, Henrik; Aly, Markus; Szulkin, Robert; Eklund, Martin; Nordström, Tobias; Pashayan, Nora; M. Dunning, Alison; Ghoussaini, Maya; C. Travis, Ruth; J. Key, Timothy; Ríboli, Elio; Y. Park, Jong; A. Sellers, Thomas; Lin, Hui‐Yi; Albanes, Demetrius; J. Weinstein, Stephanie; A. Mucci, Lorelei; L. Giovannucci, Edward; Lindström, Sara; Kraft, Peter; J. Hunter, David; L. Penney, Kathryn; Turman, Constance; M. Tangen, Catherine; J. Goodman, Phyllis; M. Thompson, Ian; J. Hamilton, Robert; E. Fleshner, Neil; Finelli, Antonio; Parent, Marie‐Elise; L. Stanford, Janet; A. Ostrander, Elaine; S. Geybels, Milan; Koutros, Stella; E. Beane Freeman, Laura; J. Stampfer, Meir; Wolk, Alicja; Håkansson, Niclas; L. Andriole, Gerald; N. Hoover, Robert; J. Machiela, Mitchell; D. Sørensen, Karina; Borre, Michael; J. Blot, William; Zheng, Wei; D. Yeboah, Edward; E. Mensah, James; Lu, Yong‐Jie; Zhang, Hong-Wei; Feng, Ninghan; Mao, Xueying; Wu, Yudong; Zhao, Shan‐Chao; Sun, Zan; N. Thibodeau, Stephen; K. McDonnell, Shannon; J. Schaid, Daniel; West, Catharine; Burnet, N.G.; Barnett, Gill; Maier, Christiane; Schnoeller, Thomas; Luedeke, Manuel; S. Kibel, Adam; F. Drake, Bettina; Cussenot, Olivier; Cancel‐Tassin, Géraldine; Ménégaux, F.; Truong, Thérèse; Akoli Koudou, Yves; M. John, Esther; Marie Grindedal, Eli; Mæhle, Lovise; Khaw, Kay‐Tee; A. Ingles, Sue; C. Stern, Mariana; Vega, Ana; Gómez‐Caamaño, Antonio; Fachal, Laura; S. Rosenstein, Barry; L. Kerns, Sarah; Ostrer, Harry; R. Teixeira, Manuel; Paulo, Paula; Brandão, Andreia; Watya, Stephen; Lubwama, Alexander; T. Bensen, Jeannette; T. H. Fontham, Elizabeth; L. Mohler, James; A. Taylor, Jack; Kogevinas, Manolis; Llorca, Javier; Castaño‐Vinyals, Gemma; Cannon‐Albright, Lisa; C. Teerlink, Craig; D. Huff, Chad; S. Strom, Sara; Multigner, Luc; Blanchet, Pascal; Brureau, Laurent; Kaneva, Radka; Slavov, Chavdar; Mitev, Vanio; J. Leach, Robin; Weaver, Brandi; Brenner, Hermann; Ćuk, Katarina; Holleczek, Bernd; Saum, Kai-Uwe; A. Klein, Eric; W. Hsing, Ann; A. Kittles, Rick; B. Murphy, Adam; J. Logothetis, Christopher; Kim, Jeri; L. Neuhausen, Susan; Steele, Linda; Chun Ding, Yuan; B. Isaacs, William; Nemesure, Barbara; Hennis, Anselm; Carpten, John; Pandha, Hardev; Michael, Agnieszka; De Ruyck, Kim; De Meerleer, Gert; Ost, Piet; Xu, Jianfeng; Hassan Abdul Razack, Azad; Lim, Jasmine; Teo, Soo‐Hwang; F. Newcomb, Lisa; Lin, Daniel; H. Fowke, Jay; Neslund‐Dudas, Christine; A. Rybicki, Benjamin; Gamulin, Marija; Lessel, Davor; Kuliš, Tomislav; Usmani, Nawaid; K. Singhal, Sandeep; Parliament, Matthew; Claessens, Frank; Joniau, Steven; Van den Broeck, Thomas; Gago-Domínguez, Manuela; E. Castelao, Jose; Elena Martı́nez, Marı́a; Larkin, Samantha; A. Townsend, Paul; Aukim-Hastie, Claire; S. Bush, William; C. Aldrich, Melinda; C. Crawford, Dana; Srivastava, Shiv; Cullen, Jennifer; Petrovics, György; Casey, Graham; J. Roobol, Monique; Jenster, Guido; H. N. van Schaik, Ron; J. Hu, Jennifer; Sanderson, Maureen; Varma, Rohit; McKean‐Cowdin, Roberta; Torres, Mina; Mancuso, Nicholas; I. Berndt, Sonja; K. Van Den Eeden, Stephen; F. Easton, Douglas; J. Chanock, Stephen; B. Cook, Michael; Wiklund, Fredrik; Nakagawa, Hidewaki; S. Witte, John; A. Eeles, Rosalind; Kote‐Jarai, Zsofia; A. Haiman, Christopher

doi:10.1038/s41588-020-00748-0

Public

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

Published in Nature Genetics • Jan 1, 2021

Authors:

David V. Conti

Burcu F. Darst

Lilit C. Moss

Abstract

Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independ...

Subject

Prostate cancer

Odds ratio

Biology

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