SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species

Moustaqil, Mehdi; Ollivier, Emma; Chiu, Hsin-Ping; van Tol, Sarah; Soto, Paulina; S. Stevens, Christian; Bhumkar, Akshay; J. B. Hunter, Dominic; N. Freiberg, Alexander; A. Jacques, David; Lee, Benhur; Sierecki, Emma; Gambin, Yann

doi:10.1080/22221751.2020.1870414

Public

SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species

Published in Emerging Microbes & Infections • Dec 29, 2020

Authors:

Mehdi Moustaqil

Emma Ollivier

Hsin-Ping Chiu

Abstract

The genome of SARS-CoV-2 encodes two viral proteases (NSP3/papain-like protease and NSP5/3C-like protease) that are responsible for cleaving viral polyproteins during replication. Here, we discovered new functions of the NSP3 and NSP5 proteases of SARS-CoV-2, demonstrating that they could directly c...

Subject

Proteases

Protease

Cleave

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!