STOML2 potentiates metastasis of hepatocellular carcinoma by promoting PINK1-mediated mitophagy and regulates sensitivity to lenvatinib

Zheng, Yahui; Huang, Chong; Lu, Lu; Yu, Kang‐Kang; Zhao, Jing; Chen, Mingquan; Liu, Lu; Sun, Qingfeng; Lin, Zhifei; Zheng, Jianming; Chen, Jinhong; Zhang, Jubo

doi:10.1186/s13045-020-01029-3

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STOML2 potentiates metastasis of hepatocellular carcinoma by promoting PINK1-mediated mitophagy and regulates sensitivity to lenvatinib

Published in Journal of Hematology & Oncology • Jan 14, 2021

Authors:

Yahui Zheng

Chong Huang

Lu Lu

Abstract

BACKGROUND: Dysregulation of both mitochondrial biogenesis and mitophagy is critical to sustain oncogenic signaling pathways. However, the mechanism of mitophagy in promoting hepatocellular carcinoma (HCC) progression remains poorly understood. In this study, we investigated the clinical significanc...

Subject

Mitophagy

Cancer research

Downregulation and upregulation

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