Hypoxic hUCMSC-derived extracellular vesicles attenuate allergic airway inflammation and airway remodeling in chronic asthma mice

Dong, Liyang; Wang, Ying; Zheng, Tingting; Pu, Yanan; Ma, Yongbin; Qi, Xin; Zhang, Wenzhe; Xue, Fei; Shan, Zirui; Liu, Jiameng; Wang, Xuefeng; Mao, Chaoming

doi:10.1186/s13287-020-02072-0

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Hypoxic hUCMSC-derived extracellular vesicles attenuate allergic airway inflammation and airway remodeling in chronic asthma mice

Shared by NobleBlocks on Jan 6, 2021 • 12:00 AM UTC

Authors:

Liyang Dong

Ying Wang

Tingting Zheng

Abstract

Abstract Background As one of the main functional forms of mesenchymal stem cells (MSCs), MSC-derived extracellular vesicles (MSC-EVs) have shown an alternative therapeutic option in experimental models of allergic asthma. Oxygen concentration plays an important role in the self-renewal, proliferati...

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