Cardioprotective mechanism of SGLT2 inhibitor against myocardial infarction is through reduction of autosis

Jiang, Kai; Xu, Yue; Wang, Dandan; Chen, Feng; Tu, Zizhuo; Qian, Jie; Xu, Sheng; Xu, Yixiang; Hwa, John; Li, Jian; Shang, Hongcai; Xiang, Yaozu

doi:10.1007/s13238-020-00809-4

Public

Cardioprotective mechanism of SGLT2 inhibitor against myocardial infarction is through reduction of autosis

Published in Protein & Cell • Jan 8, 2021

Authors:

Kai Jiang

Yue Xu

Dandan Wang

Abstract

Abstract Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce cardiovascular mortality in patients with diabetes mellitus but the protective mechanism remains elusive. Here we demonstrated that the SGLT2 inhibitor, Empagliflozin (EMPA), suppresses cardiomyocytes autosis (autophagic cell death) t...

Subject

Empagliflozin

Autophagy

Diabetes mellitus

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