Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

Koenig, Paul-Albert; Das, Hrishikesh; Liu, Hejun; M. Kümmerer, Beate; N. Gohr, Florian; Jenster, Lea-Marie; D. J. Schiffelers, Lisa; M. Tesfamariam, Yonas; Uchima, Miki; D. Wuerth, Jennifer; Gatterdam, Karl; Ruetalo, Natalia; H. Christensen, Maria; I. Fandrey, Caroline; Normann, Sabine; M. P. Tödtmann, Jan; Pritzl, Steffen; Hanke, Leo; Boos, Jannik; Yuan, Meng; Zhu, Xueyong; L. Schmid-Burgk, Jonathan; Kato, Hiroki; Schindler, Michael; A. Wilson, Ian; Geyer, Matthias; U. Ludwig, Kerstin; Martin Hällberg, B.; C. Wu, Nicholas; I. Schmidt, Florian

doi:10.1126/science.abe6230

Public

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

Shared by NobleBlocks on Feb 12, 2021 • 12:00 AM UTC

Authors:

Paul-Albert Koenig

Hrishikesh Das

Hejun Liu

Abstract

A double punch against SARS-CoV-2 Monoclonal antibodies are an important weapon in the battle against COVID-19. However, these large proteins are difficult to produce in the needed quantities and at low cost. Attention has turned to nanobodies, which are aptly named, single-domain antibodies that ar...

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