Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

Koenig, Paul-Albert; Das, Hrishikesh; Liu, Hejun; M. Kümmerer, Beate; N. Gohr, Florian; Jenster, Lea‐Marie; D. J. Schiffelers, Lisa; M. Tesfamariam, Yonas; Uchima, Miki; Deborah Wuerth, Jennifer; Gatterdam, Karl; Ruétalo, Natalia; H. Christensen, Maria; I. Fandrey, Caroline; Normann, Sabine; M. P. Tödtmann, Jan; Pritzl, Steffen; Hanke, Leo; Boos, Jannik; Yuan, Meng; Zhu, Xueyong; L. Schmid‐Burgk, Jonathan; Kato, Hiroki; Schindler, Michael; A. Wilson, Ian; Geyer, Matthias; U. Ludwig, Kerstin; Hallberg, B.M.; C. Wu, Nicholas; I. Schmidt, Florian

doi:10.1126/science.abe6230

Public

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

Published in Science • Jan 12, 2021

Authors:

Paul-Albert Koenig

Hrishikesh Das

Hejun Liu

Abstract

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread, with devastating consequences. For passive immunization efforts, nanobodies have size and cost advantages over conventional antibodies. In this study, we generated four neutralizing nanobodies th...

Subject

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Block (permutation group theory)

Virology

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