Venetoclax induces deep hematologic remissions in t(11;14) relapsed/refractory AL amyloidosis

Premkumar, Vikram; Lentzsch, Suzanne; Pan, Samuel; Bhutani, Divaya; Richter, Joshua; Jagannath, Sundar; Liedtke, Michaela; Jaccard, Arnaud; Wechalekar, Ashutosh; L. Comenzo, Raymond; Sanchorawala, Vaishali; Royer, Bruno; Rosenzweig, Michael; Valent, Jason; Schönland, Stefan; Fonseca, Rafaël; W. Wong, Sandy; Kapoor, Prashant

doi:10.1038/s41408-020-00397-w

Public

Venetoclax induces deep hematologic remissions in t(11;14) relapsed/refractory AL amyloidosis

Published in Blood Cancer Journal • Jan 11, 2021

Authors:

Vikram Premkumar

Suzanne Lentzsch

Samuel Pan

Abstract

Venetoclax is efficacious in relapsed/refractory t(11;14) multiple myeloma, thus warranting investigation in light-chain amyloidosis (AL). This retrospective cohort includes 43 patients with previously treated AL, from 14 centers in the US and Europe. Thirty-one patients harbored t(11;14), 11 did no...

Subject

Internal medicine

Medicine

Venetoclax

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