A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma

Ma, Sai; Zhou, Bo; Yang, Qian; Pan, Yunzhi; Yang, Wei; J. Freedland, Stephen; Ding, Ling‐Wen; R. Freeman, Michael; J. Breunig, Joshua; A. Bhowmick, Neil; Pan, Jian; Phillip Koeffler, H.; Lin, De‐Chen

doi:10.1158/0008-5472.can-20-0652

Public

A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma

Published in Cancer Research • Jan 5, 2021

Authors:

Sai Ma

Bo Zhou

Qian Yang

Abstract

Abstract Although obesity is one of the strongest risk factors for esophageal adenocarcinoma, the molecular mechanisms underlying this association remain unclear. We recently identified four esophageal adenocarcinoma–specific master regulator transcription factors (MRTF) ELF3, KLF5, GATA6, and EHF. ...

Subject

Peroxisome proliferator-activated receptor gamma

Cancer research

Biology

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