A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma.

S, Ma; B, Zhou; Q, Yang; Y, Pan; W, Yang; SJ, Freedland; LW, Ding; MR, Freeman; JJ, Breunig; NA, Bhowmick; J, Pan; HP, Koeffler; DC, Lin

doi:10.1158/0008-5472.can-20-0652

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A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma.

Shared by NobleBlocks on Jan 5, 2021 • 12:00 AM UTC

Authors:

Ma S

Zhou B

Yang Q

Abstract

Although obesity is one of the strongest risk factors for esophageal adenocarcinoma, the molecular mechanisms underlying this association remain unclear. We recently identified four esophageal adenocarcinoma-specific master regulator transcription factors (MRTF) ELF3, KLF5, GATA6, and EHF. In this s...

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