The integration of immune checkpoint inhibitors with VEGF targeted agents in advanced gastric and gastroesophageal adenocarcinoma: a review on the rationale and results of early phase trials

Saeed, Anwaar; Park, Robin; Sun, Weijing

doi:10.1186/s13045-021-01034-0

Public

The integration of immune checkpoint inhibitors with VEGF targeted agents in advanced gastric and gastroesophageal adenocarcinoma: a review on the rationale and results of early phase trials

Published in Journal of Hematology & Oncology • Jan 12, 2021

Authors:

Anwaar Saeed

Robin Park

Weijing Sun

Abstract

Several targeted therapies have shown efficacy in patients with advanced gastric cancer (GC) and gastroesophageal junction adenocarcinoma (GEJC), including anti-angiogenic agents and immune checkpoint inhibitors. Ramucirumab, an anti-VEGFR2 antibody, has shown efficacy in GC, but the benefits are li...

Subject

Medicine

Cabozantinib

Pembrolizumab

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