circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity

Li, Botai; Zhu, Lili; Lu, Chunlai; Wang, Cun; Wang, Hui; Jin, Haojie; Ma, Xuhui; Cheng, Zhuoan; Yu, Chengtao; Wang, Siying; Zuo, Qiaozhu; Zhou, Yangyang; Wang, Jun; Yang, Chen; Lv, Yuanyuan; Jiang, Liyan; Qin, Wenxin

doi:10.1038/s41467-020-20527-z

Public

circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity

Published in Nature Communications • Jan 12, 2021

Authors:

Botai Li

Lili Zhu

Chunlai Lu

Abstract

Abstract Circular RNAs (circRNA) are a class of covalently closed single-stranded RNAs that have been implicated in cancer progression. Here we identify circNDUFB2 to be downregulated in non-small cell lung cancer (NSCLC) tissues, and to negatively correlate with NSCLC malignant features. Elevated c...

Subject

Tumor progression

Ubiquitin

Metastasis

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