Human umbilical cord mesenchymal stem cell-derived exosomal miR-27b attenuates subretinal fibrosis via suppressing epithelial–mesenchymal transition by targeting HOXC6

Li, Dongli; Zhang, Junxiu; Liu, Zijia; Gong, Yuanyuan; Zheng, Zhi

doi:10.1186/s13287-020-02064-0

Public

Human umbilical cord mesenchymal stem cell-derived exosomal miR-27b attenuates subretinal fibrosis via suppressing epithelial–mesenchymal transition by targeting HOXC6

Published in Stem Cell Research & Therapy • Jan 7, 2021

Authors:

Dongli Li

Junxiu Zhang

Zijia Liu

Abstract

BACKGROUND AND AIM: Subretinal fibrosis resulting from neovascular age-related macular degeneration (nAMD) is one of the major causes of serious and irreversible vision loss worldwide, and no definite and effective treatment exists currently. Retinal pigmented epithelium (RPE) cells are crucial in m...

Subject

Mesenchymal stem cell

Microvesicles

Epithelial–mesenchymal transition

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