Effect of Lowering V t on Mortality in Acute Respiratory Distress Syndrome Varies with Respiratory System Elastance

C. Goligher, Ewan; Leite Vieira Costa, Eduardo; J. Yarnell, Christopher; Brochard, Laurent; E. Stewart, Thomas; Tomlinson, George; G. Brower, Roy; S. Slutsky, Arthur; B. P. Amato, Marcelo

doi:10.1164/rccm.202009-3536oc

Public

Effect of Lowering V t on Mortality in Acute Respiratory Distress Syndrome Varies with Respiratory System Elastance

Published in American Journal of Respiratory and Critical Care Medicine • Jan 13, 2021

Authors:

Ewan C. Goligher

Eduardo Leite Vieira Costa

Christopher J. Yarnell

Abstract

Abstract Rationale If the risk of ventilator-induced lung injury in acute respiratory distress syndrome (ARDS) is causally determined by driving pressure rather than by Vt, then the effect of ventilation with lower Vt on mortality would be predicted to vary according to respiratory system elastance ...

Subject

Medicine

Elastance

Acute respiratory distress

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