Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells

Ding, Yahui; Chen, Xiaoping; Liu, Can; Ge, Weizhi; Wang, Qin; Hao, Xin; Wang, Mengmeng; Chen, Yue; Zhang, Quan

doi:10.1186/s13045-020-01016-8

Public

Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells

Published in Journal of Hematology & Oncology • Jan 20, 2021

Authors:

Yahui Ding

Xiaoping Chen

Can Liu

Abstract

BACKGROUND: TNBC is the most aggressive breast cancer with higher recurrence and mortality rate than other types of breast cancer. There is an urgent need for identification of therapeutic agents with unique mode of action for overcoming current challenges in TNBC treatment. METHODS: Different inhib...

Subject

Apoptosis

Cancer research

EGR1

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