The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway

Wang, Fang; Zhang, Ye; Shen, Jianliang; Yang, Bin; Dai, Weiwei; Yan, Junrong; Maimouni, Sara; Q. Daguplo, Heineken; Coppola, Sara; Gao, Yingtang; Wang, Yijun; Zhi, Du; Peng, Kesong; Liu, Hui; Zhang, Qin; Tang, Fei; Wang, Peng; Gao, Shenglan; Wang, Yongbo; Ding, Wen‐Xing; L. Guo, Grace; Wang, Fengmei; Zong, Wei‐Xing

doi:10.1016/j.jcmgh.2021.01.007

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The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway

Published in Cellular and Molecular Gastroenterology and Hepatology • Jan 1, 2021

Authors:

Fang Wang

Ye Zhang

Jianliang Shen

Abstract

BACKGROUND AND AIMS: TRIM21 is a ubiquitin E3 ligase that is implicated in numerous biological processes including immune response, cell metabolism, redox homeostasis, and cancer development. We recently reported that TRIM21 can negatively regulate the p62-Keap1-Nrf2 antioxidant pathway by ubiquityl...

Subject

Ubiquitin ligase

KEAP1

Ubiquitin

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