Universal DNA methylation age across mammalian tissues

Lu, Aimei; Fei, Zhe; Haghani, Amin; R. Robeck, Todd; A. Zoller, Joseph; Li, Chengzhang; Lowe, Robert; Yan, Qi; Zhang, Joshua; Vu, Hoang‐Giang; Ablaeva, Julia; A. Acosta-Rodríguez, Victoria; M. Adams, Denise; Almunia, Javier; Aloysius, Ajoy; Ardehali, Reza; Arneson, A; Scott Baker, C.; Banks, Gareth; Belov, Katherine; C. Bennett, Nigel; McL. Black, Peter; T. Blumstein, Daniel; K. Bors, Eleanor; E. Breeze, Charles; T. Brooke, Robert; L. Brown, Janine; Carter, G.; Caulton, Alex; M. Cavin, Julie; Chakrabarti, Lisa; Chatzistamou, Ioulia; Chen, Hao; Cheng, Kai; Chiavellini, Priscila; Choi, Oi‐Wa; Clarke, Shannon; Noelle Cooper, Lisa; Cossette, Marie‐Laurence; Day, Joanna; DeYoung, Joseph; DiRocco, Stacy; Dold, Christopher; E. Ehmke, Erin; K. Emmons, Candice; Emmrich, Stephan; Erbay, Ebru; Erlacher‐Reid, Claire; G. Faulkes, Christopher; H. Ferguson, Steven; J. Finno, Carrie; E. Flower, Jennifer; Gaillard, Jean‐Michel; Garde, Eva; Gerber, Livia; N. Gladyshev, Vadim; Gorbunova, Vera; G. Goya, Rodolfo; J. Grant, Maria; Green, C.B.; N. Hales, Erin; Bradley Hanson, M.; W. Hart, Daniel; Haulena, Martin; Herrick, K.; N. Hogan, Andrew; J. Hogg, Carolyn; Hore, T.A.; Huang, Taosheng; Carlos Izpisúa Belmonte, Juan; J. Jasinska, Anna; Jones, Gareth; Jourdain, Eve; Kashpur, Olga; L. Katcher, Harold; Katsumata, Etsuko; Kaza, Vimala; Kiaris, Hippokratis; S. Kobor, Michael; Kordowitzki, Paweł; R. Koski, William; Kruetzen, Michael; Kwon, Soon‐Bae; Larison, Brenda; Lee, Sang‐Goo; Lehmann, Marina; Lemaître, Jean‐François; J. Levine, Andrew; Li, Chengzhang; Li, X.; Lim, A.; Lin, David; Lindemann, D.; J. Little, Tom; Macoretta, Nicholas; Maddox, Debra; O. Matkin, Craig; A. Mattison, Julie; McClure, Mélanie; Mergl, June; Meudt, J.J.; Montano, Gisele; Mozhui, Khyobeni; Munshi‐South, Jason; Naderi, Asieh; Nagy, Martina; Narayan, Pritika; W. Nathanielsz, Peter; Bích Nguỹên, Ngọc; Niehrs, Christof; K. O’Brien, Justine; O’Tierney-Ginn, Perrie; T. Odom, Duncan; G. Ophir, Alexander; B. Osborn, S.; A. Ostrander, Elaine; M. Parsons, Kim; Paul, Kaninika; Pellegrini, Matteo; Peters, Klaus; B. Pedersen, Amy; L. Petersen, Jessica; W. Pietersen, Darren; Medeiros de Pinho, Gabriela; Plassais, Jocelyn; R. Poganik, Jesse; A. Prado, Natalia; Reddy, Pradeep; Rey, Benjamin; Ritz, Beate; Robbins, Jooke; Rodríguez, Magdalena; Russell, Jennifer; Rydkina, Elena; L. Sailer, Lindsay; B. Salmon, Adam; Sanghavi, Akshay; M. Schachtschneider, Kyle; Schmitt, Dennis; L. Schmitt, Todd; Schomacher, Lars; B. Schook, Lawrence; E. Sears, Karen; W. Seifert, Ashley; Seluanov, Andrei; B. A. Shafer, Aaron; Shanmuganayagam, Dhanansayan; V. Shindyapina, Anastasia; Simmons, M.; Singh, Kavita; Sinha, Indranil; Slone, Jesse; G. Snell, Russell; Soltanmaohammadi, E.; L Spangler, Matthew; Spriggs, Maria; Staggs, Lydia; Stedman, Nicole; J. Steinman, Karen; T. Stewart, Donald; J Sugrue, Victoria; Szladovits, Balázs; S. Takahashi, Joseph; Takasugi, M.; C. Teeling, Emma; J. Thompson, Michael; Van Bonn, B.; C. Vernes, Sonja; Villar, Diego; V. Vinters, Harry; C. Wallingford, Mary; Wang, Nan; K. Wayne, Robert; S. Wilkinson, Gerald; Williams, CK; W. Williams, Robert; William Yang, X.; Yao, M.; G. Young, B.; Zhang, Bohan; Zhang, Zhihui; Zhao, Peng; Zhao, Yang; Zhou, Wei; Zimmermann, Jörg; Ernst, Jason; Raj, K.; Horvath, Steve

doi:10.1101/2021.01.18.426733

Public

Universal DNA methylation age across mammalian tissues

Published in bioRxiv (Cold Spring Harbor Laboratory) • Jan 19, 2021

Authors:

Aimei Lu

Zhe Fei

Amin Haghani

Abstract

ABSTRACT Aging is often perceived as a degenerative process resulting from random accrual of cellular damage over time. Despite this, age can be accurately estimated by epigenetic clocks based on DNA methylation profiles from almost any tissue of the body. Since such pan-tissue epigenetic clocks hav...

Subject

Epigenetics

Biology

DNA methylation

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