Hypoxia‐induced FOXO4/LDHA axis modulates gastric cancer cell glycolysis and progression

Wang, Xiaohong; Jiang, Zhonghua; Yang, Hongmei; Zhang, Yu; Xu, Lihua

doi:10.1002/ctm2.279

Public

Hypoxia‐induced FOXO4/LDHA axis modulates gastric cancer cell glycolysis and progression

Published in Clinical and Translational Medicine • Jan 1, 2021

Authors:

Xiaohong Wang

Zhonghua Jiang

Hongmei Yang

Abstract

BACKGROUND AND AIM: We previously identified forkhead box (FOX) O4 mRNA as a predictor in gastric cancer (GC). However, the underlying mechanism has yet to be elucidated. We aimed to illustrate the mechanism by which FOXO4 regulated glycolysis under hypoxia in GC. METHODS: FOXO4 protein expression w...

Subject

Glycolysis

Lactate dehydrogenase

Cancer research

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