CAR T cells in solid tumors: challenges and opportunities

Marofi, Faroogh; Motavalli, Roza; A. Safonov, Vladimir; Thangavelu, Lakshmi; Valerievich Yumashev, Alexei; Alexander, Markov; Shomali, Navid; Stanley Chartrand, Max; Pathak, Yashwant; Jarahian, Mostafa; Izadi, Sepideh; Hassanzadeh, Ali; Shirafkan, Naghmeh; Tahmasebi, Safa; Motavalli Khiavi, Farhad

doi:10.1186/s13287-020-02128-1

Public

CAR T cells in solid tumors: challenges and opportunities

Shared by NobleBlocks on Jan 25, 2021 • 12:00 AM UTC

Authors:

Faroogh Marofi

Roza Motavalli

Vladimir A. Safonov

Abstract

Abstract Background CARs are simulated receptors containing an extracellular single-chain variable fragment (scFv), a transmembrane domain, as well as an intracellular region of immunoreceptor tyrosine-based activation motifs (ITAMs) in association with a co-stimulatory signal. Main body Chimeric an...

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