SARS-CoV-2 Triggers an MDA-5-Dependent Interferon Response Which Is Unable To Control Replication in Lung Epithelial Cells

Rebendenne, Antoine; Luiza Chaves Valadão, Ana; Tauziet, Marine; Maarifi, Ghizlane; Bonaventure, Boris; McKellar, Joe; Planès, Rémi; Nisole, Sébastien; Arnaud-Arnould, Mary; Moncorgé, Olivier; Goujon, Caroline

doi:10.1128/jvi.02415-20

Public

SARS-CoV-2 Triggers an MDA-5-Dependent Interferon Response Which Is Unable To Control Replication in Lung Epithelial Cells

Shared by NobleBlocks on Mar 25, 2021 • 12:00 AM UTC

Authors:

Antoine Rebendenne

Ana Luiza Chaves Valadão

Marine Tauziet

Abstract

Mammalian cells express sensors able to detect specific features of pathogens and induce the interferon response, which is one of the first lines of defense against viruses and helps in controlling viral replication. The mechanisms and impact of SARS-CoV-2 sensing in lung epithelial cells remain to ...

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