SARS-CoV-2 Triggers an MDA-5-Dependent Interferon Response Which Is Unable To Control Replication in Lung Epithelial Cells

Rebendenne, Antoine; Luiza Chaves Valadão, Ana; Tauziet, Marine; Maarifi, Ghizlane; Bonaventure, Boris; McKellar, Joe; Planès, Rémi; Nisole, Sébastien; Arnaud‐Arnould, Mary; Moncorgé, Olivier; Goujon, Caroline

doi:10.1128/jvi.02415-20

Public

SARS-CoV-2 Triggers an MDA-5-Dependent Interferon Response Which Is Unable To Control Replication in Lung Epithelial Cells

Published in Journal of Virology • Jan 29, 2021

Authors:

Antoine Rebendenne

Ana Luiza Chaves Valadão

Marine Tauziet

Abstract

Mammalian cells express sensors able to detect specific features of pathogens and induce the interferon response, which is one of the first line of defenses against viruses and help controlling viral replication. The mechanisms and impact of SARS-CoV-2 sensing in lung epithelial cells remained to be...

Subject

Biology

Viral replication

Interferon

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