A Biomimetic Drug Delivery System by Integrating Grapefruit Extracellular Vesicles and Doxorubicin-Loaded Heparin-Based Nanoparticles for Glioma Therapy

Niu, Wenbo; Xiao, Qian; Wang, Xuejiao; Zhu, Junqiao; Li, Jin‐Heng; Liang, Xiaomei; Peng, Yingming; Wu, Chentian; Lu, Ruojing; Pan, Yao; Luo, Jiamao; Zhong, Xinxian; He, Haoqi; Rong, Zhili; Fan, Jun‐Bing; Wang, Ying

doi:10.1021/acs.nanolett.0c04753

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A Biomimetic Drug Delivery System by Integrating Grapefruit Extracellular Vesicles and Doxorubicin-Loaded Heparin-Based Nanoparticles for Glioma Therapy

Published in Nano Letters • Jan 21, 2021

Authors:

Wenbo Niu

Qian Xiao

Xuejiao Wang

Abstract

Existing nanoparticle-mediated drug delivery systems for glioma systemic chemotherapy remain a great challenge due to poor delivery efficiency resulting from the blood brain barrier/blood-(brain tumor) barrier (BBB/BBTB) and insufficient tumor penetration. Here, we demonstrate a distinct design by p...

Subject

Glioma

Drug delivery

Transcytosis

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