SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

Kurt Wibmer, Constantinos; Ayres, Frances; Hermanus, Tandile; Madzivhandila, Mashudu; Kgagudi, Prudence; Oosthuysen, Brent; E. Lambson, Bronwen; de Oliveira, Túlio; Vermeulen, Marion; van den Berg, Karin; M. Rossouw, Theresa; T. Boswell, Michael; Ueckermann, Veronica; Meiring, Susan; von Gottberg, Anne; Cohen, Cheryl; Morris, Lynn; N. Bhiman, Jinal; L. Moore, Penny

doi:10.1101/2021.01.18.427166

Public

SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

Published in bioRxiv (Cold Spring Harbor Laboratory) • Jan 19, 2021

Authors:

Constantinos Kurt Wibmer

Frances Ayres

Tandile Hermanus

Abstract

SARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein. Here, we show that pseudovirus expressing 501Y.V2 spike protein completely escapes three classes of therapeutically relevant antibodies. This pseu...

Subject

Neutralization

Spike Protein

Convalescent plasma

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