Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape

Ku, Zhiqiang; Xie, Xuping; Davidson, Edgar; Ye, Xiaohua; Su, Hang; D. Menachery, Vineet; Li, Yize; Yuan, Zihao; Zhang, Xianwen; E. Muruato, Antonio; Grinyo i Escuer, Ariadna; Tyrell, Breanna; Doolan, Kyle; J. Doranz, Benjamin; Wrapp, Daniel; Bates, Paul; S. McLellan, Jason; R. Weiss, Susan; Zhang, Ningyan; Shi, Pei‐Yong; An, Zhiqiang

doi:10.1038/s41467-020-20789-7

Public

Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape

Published in Nature Communications • Jan 20, 2021

Authors:

Zhiqiang Ku

Xuping Xie

Edgar Davidson

Abstract

Antibody cocktails represent a promising approach to prevent SARS-CoV-2 escape. The determinants for selecting antibody combinations and the mechanism that antibody cocktails prevent viral escape remain unclear. We compared the critical residues in the receptor-binding domain (RBD) used by multiple ...

Subject

Antibody

Epitope

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

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