Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients

T. Tan, Anthony; Linster, Martin; Wah Tan, Chee; Le Bert, Nina; Ni Chia, Wan; Kunasegaran, Kamini; Zhuang, Yan; Tham, C; Chia, Adeline; J. D. Smith, Gavin; Edward Young, Barnaby; Kalimuddin, Shirin; G. Low, Jenny; Chien Lye, David; Wang, Lin‐Fa; Bertoletti, Antonio

doi:10.1016/j.celrep.2021.108728

Public

Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients

Published in Cell Reports • Jan 21, 2021

Authors:

Anthony T. Tan

Martin Linster

Chee Wah Tan

Abstract

Virus-specific humoral and cellular immunity act synergistically to protect the host from viral infection. We interrogate the dynamic changes of virological and immunological parameters in 12 patients with symptomatic acute SARS-CoV-2 infection from disease onset to convalescence or death. We quanti...

Subject

Convalescence

Immune system

Immunology

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