Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages

Wauters, Els; Van Mol, Pierre; D. Garg, Abhishek; Jansen, Sander; Van Herck, Yannick; Vanderbeke, Lore; Bassez, Ayse; Boeckx, Bram; Malengier‐Devlies, Bert; Timmerman, Anna; Van Brussel, Thomas; Van Buyten, Tina; Schepers, Rogier; Heylen, Elisabeth; Dauwe, Dieter; Dooms, Christophe; Gunst, Jan; Hermans, Greet; Meersseman, Philippe; Testelmans, Dries; Yserbyt, Jonas; Tejpar, Sabine; De Wever, Walter; Matthys, Patrick; collaborators, CONTAGIOUS; M. Bosisio, Francesca; P. Casaer, Michaël; De Smet, Frederik; De Munter, Paul; Humblet‐Baron, Stéphanie; Liston, Adrian; Lorent, Natalie; Martinod, Kimberly; Proost, Paul; Raes, Jeroen; Thevissen, Karin; Vos, Robin; Weynand, Birgit; Wouters, Carine; Neyts, Johan; Wauters, Joost; Qian, Junbin; Lambrechts, Diether

doi:10.1038/s41422-020-00455-9

Public

Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages

Published in Cell Research • Jan 20, 2021

Authors:

Els Wauters

Pierre Van Mol

Abhishek D. Garg

Abstract

Abstract How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated. Here, we perform single-cell deep-immune profiling of bronchoalveolar lavage (BAL) samples from 5 patients with mild and 26 with critical COVID-19 in comparison to...

Subject

Immunology

Biology

Bronchoalveolar lavage

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