Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups

Wang, Yongfei; Zhang, Yan; Lin, Zhiming; Zhang, Huoru; Wang, Ting-You; Cao, Yujie; Morris, David; Sheng, Yujun; Yin, Xianyong; Zhong, Shi-Long; Gu, Xiaoqiong; Yao, Lei; He, Jing; Wu, Qi; Jane Shen, Jiangshan; Yang, Jing; Lam, Tai-Hing; Lin, Jia-Huang; Mai, Zhi‐Ming; Guo, Mengbiao; Tang, Yuanjia; Chen, Yanhui; Song, Qin; Ban, Bo; Chiu Mok, Chi; Cui, Yong; Lu, Liangjing; Shen, Nan; C. Sham, Pak; Sing Lau, Chak; K. Smith, David; J. Vyse, Timothy; Zhang, Xuejun; Lau, YL; Yang, Wanling

doi:10.1038/s41467-021-21049-y

Public

Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups

Published in Nature Communications • Feb 3, 2021

Authors:

Yongfei Wang

Yan Zhang

Zhiming Lin

Abstract

Systemic lupus erythematosus (SLE), a worldwide autoimmune disease with high heritability, shows differences in prevalence, severity and age of onset among different ancestral groups. Previous genetic studies have focused more on European populations, which appear to be the least affected. Consequen...

Subject

Genome-wide association study

Disease

Human leukocyte antigen

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