Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity

C. Thomson, Emma; E. Rosen, Laura; G. Shepherd, James; Spreafico, Roberto; da Silva Filipe, Ana; A. Wojcechowskyj, Jason; Davis, Christopher; Piccoli, Luca; J. Pascall, David; R. Dillen, Josh; Lytras, Spyros; Czudnochowski, Nadine; Shah, Rajiv; Meury, Marcel; Jesudason, Natasha; De Marco, Anna; Li, Kathy; Bassi, Jessica; O’Toole, Áine; Pinto, Dora; Colquhoun, Rachel; Culap, Katja; Jackson, Ben; Zatta, Fabrizia; Rambaut, Andrew; Jaconi, Stefano; B. Sreenu, Vattipally; C. Nix, Jay; Zhang, Ivy; F. Jarrett, Ruth; G. Glass, William; Beltramello, Martina; Nomikou, Kyriaki; Samuele Pizzuto, Matteo; Tong, L.; Cameroni, Elisabetta; I. Croll, Tristan; Johnson, Natasha; di Iulio, Julia; Wickenhagen, Arthur; Ceschi, Alessandro; M. Harbison, Aoife; Mair, Daniel; Ferrari, Paolo; Smollett, Katherine; Sallusto, Federica; Carmichael, Stephen; Garzoni, Christian; Nichols, Jenna; Galli, Massimo; Hughes, Joseph; Riva, Agostino; Ho, Antonia; Schiuma, Marco; G. Semple, Malcolm; Openshaw, Peter; Fadda, Elisa; Kenneth Baillie, J.; D. Chodera, John; J. Rihn, Suzannah; Lycett, Samantha; W. Virgin, Herbert; Telenti, Amalio; Corti, Davide; L. Robertson, David; Snell, Gyorgy

doi:10.1016/j.cell.2021.01.037

Public

Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity

Published in Cell • Jan 28, 2021

Authors:

Emma C. Thomson

Laura E. Rosen

James G. Shepherd

Abstract

SARS-CoV-2 can mutate and evade immunity, with consequences for efficacy of emerging vaccines and antibody therapeutics. Here, we demonstrate that the immunodominant SARS-CoV-2 spike (S) receptor binding motif (RBM) is a highly variable region of S and provide epidemiological, clinical, and molecula...

Subject

Biology

Spike (software development)

Immunity

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