Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.

H Nguyen, Phuong; Ramamoorthy, Ayyalusamy; R Sahoo, Bikash; Zheng, Jie; Faller, Peter; E Straub, John; Dominguez, Laura; Shea, Joan-Emma; V Dokholyan, Nikolay; De Simone, Alfonso; Ma, Buyong; Nussinov, Ruth; Najafi, Saeed; Tung Ngo, Son; Loquet, Antoine; Chiricotto, Mara; Ganguly, Pritam; McCarty, James; Suan Li, Mai; Hall, Carol; Wang, Yiming; Miller, Yifat; Melchionna, Simone; Habenstein, Birgit; Timr, Stepan; Chen, Jiaxing; Hnath, Brianna; Strodel, Birgit; Kayed, Rakez; Lesné, Sylvain; Wei, Guanghong; Sterpone, Fabio; J Doig, Andrew; Derreumaux, Philippe

doi:10.1021/acs.chemrev.0c01122

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Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.

Published in Chemical reviews • Feb 24, 2021

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Authors:

Phuong H Nguyen

,

Ayyalusamy Ramamoorthy

,

Bikash R Sahoo

Abstract

Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting either the central nervous system or a variety of peripheral tissues. Structural and dynamic characterization of all species along the pathways from monomers to fibrils is challenging by experimental and computat...

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