Integrating Clinical and Polygenic Factors to Predict Breast Cancer Risk in Women Undergoing Genetic Testing

Hughes, Elisha; Tshiaba, Placede; Wagner, Susanne; Judkins, Thaddeus; T. Rosenthal, Eric; B. Roa, Benjamin; Gallagher, Shannon; Meek, Stephanie; Dalton, Kathryn; Hedegard, Wade; A. Adami, Carol; F. Grear, Danna; M. Domchek, Susan; E. Garber, Judy; M. Lancaster, Johnathan; N. Weitzel, Jeffrey; W. Kurian, Allison; S. Lanchbury, Jerry; Gutin, Alexander; E. Robson, Mark

doi:10.1200/po.20.00246

Public

Integrating Clinical and Polygenic Factors to Predict Breast Cancer Risk in Women Undergoing Genetic Testing

Published in JCO Precision Oncology • Jan 28, 2021

Authors:

Elisha Hughes

Placede Tshiaba

Susanne Wagner

Abstract

PURPOSE Screening and prevention decisions for women at increased risk of developing breast cancer depend on genetic and clinical factors to estimate risk and select appropriate interventions. Integration of polygenic risk into clinical breast cancer risk estimators can improve discrimination. Howev...

Subject

Breast cancer

Polygenic risk score

Genetic testing

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