Biallelic loss of BCMA as a resistance mechanism to CAR T cell therapy in a patient with multiple myeloma

Samur, Mehmet; Fulciniti, Mariateresa; Aktaş Samur, Anıl; Hamid Bazarbachi, Abdul; Tai, Yu‐Tzu; Prabhala, Rao; Alonso, A.; S. Sperling, Adam; Campbell, Timothy; Petrocca, Fabio; Hege, Kristen; M. Kaiser, Shari; Avet‐Loiseau, Hervé; C. Anderson, Kenneth; C. Munshi, Nikhil

doi:10.1038/s41467-021-21177-5

Public

Biallelic loss of BCMA as a resistance mechanism to CAR T cell therapy in a patient with multiple myeloma

Published in Nature Communications • Feb 8, 2021

Authors:

Mehmet Samur

Mariateresa Fulciniti

Anıl Aktaş Samur

Abstract

BCMA targeting chimeric antigen receptor (CAR) T cell therapy has shown deep and durable responses in multiple myeloma. However, relapse following therapy is frequently observed, and mechanisms of resistance remain ill-defined. Here, we perform single cell genomic characterization of longitudinal sa...

Subject

Chimeric antigen receptor

Multiple myeloma

clone (Java method)

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