Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity

Flament, Héloïse; Rouland, Matthieu; Beaudoin, Lucie; Toubal, Amine; Bertrand, Léo; Lebourgeois, Samuel; Rousseau, Camille; Soulard, Pauline; Gouda, Zouriatou; Cagninacci, Lucie; C. Monteiro, Antoine; Hurtado-Nédelec, Margarita; Luce, Sandrine; Bailly, Sabine; Andrieu, Muriel; Saintpierre, Benjamin; Letourneur, Franck; Jouan, Youenn; Si‐Tahar, Mustapha; Baranek, Thomas; Paget, Christophe; Boîtard, Christian; Vallet‐Pichard, Anaïs; Gautier, Jean–François; Ajzenberg, Nadine; Terrier, Benjamin; Pène, Frédéric; Ghosn, Jade; Lescure, X.; Yazdanpanah, Yazdan; Visseaux, Benoît; Descamps, Diane; Timsit, Jean‐François; C. Monteiro, Renato; Lehuen, Agnès

doi:10.1038/s41590-021-00870-z

Public

Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity

Published in Nature Immunology • Feb 2, 2021

Authors:

Héloïse Flament

Matthieu Rouland

Lucie Beaudoin

Abstract

Immune system dysfunction is paramount in coronavirus disease 2019 (COVID-19) severity and fatality rate. Mucosal-associated invariant T (MAIT) cells are innate-like T cells involved in mucosal immunity and protection against viral infections. Here, we studied the immune cell landscape, with emphasi...

Subject

Immunology

Cytokine storm

Proinflammatory cytokine

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