Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism

Sun, Xiaoting; He, Xingkang; Zhang, Yin; Hosaka, Kayoko; Andersson, Patrik; Wu, Jing; Wu, Jieyu; Jing, Xu; Du, Qiqiao; Hui, Xiaoli; Ding, Bo; Guo, Ziheng; Hong, An; Liu, Xuan; Wang, Yan; Ji, Qing; Beyaert, Rudi; Yang, Yunlong; Li, Qi; Cao, Yihai

doi:10.1136/gutjnl-2020-322744

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Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism

Shared by NobleBlocks on Feb 10, 2021 • 12:00 AM UTC

Authors:

Xiaoting Sun

Xingkang He

Yin Zhang

Abstract

Objective Pancreatic ductal adenocarcinoma (PDAC) is the most lethal malignancy and lacks effective treatment. We aimed to understand molecular mechanisms of the intertwined interactions between tumour stromal components in metastasis and to provide a new paradigm for PDAC therapy. Design Two unsele...

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