Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism

Sun, Xiaoting; He, Xingkang; Zhang, Yin; Hosaka, Kayoko; Andersson, Patrik; Wu, Jing; Wu, Jieyu; Xu, Jing; Du, Qiqiao; Hui, Xiaoli; Ding, Bo; Guo, Ziheng; Hong, An; Liu, Xuan; Wang, Yan; Ji, Qing; Beyaert, Rudi; Yang, Yunlong; Li, Qi; Cao, Yihai

doi:10.1136/gutjnl-2020-322744

Public

Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism

Published in Gut • Feb 10, 2021

Authors:

Xiaoting Sun

Xingkang He

Yin Zhang

Abstract

OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is the most lethal malignancy and lacks effective treatment. We aimed to understand molecular mechanisms of the intertwined interactions between tumour stromal components in metastasis and to provide a new paradigm for PDAC therapy. DESIGN: Two unse...

Subject

Pancreatic cancer

Myofibroblast

Cancer

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