Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution

Liu, Yang; He, Shuai; Wang, Xiliang; Peng, Wan; Chen, Qiuyan; Chi, Dongmei; Chen, Jierong; Han, Bo‐Wei; Lin, Guo‐Wang; Li, Yiqi; Wang, Qian-Yu; Peng, Roujun; Wei, Panpan; Guo, Xiang; Li, Bo; Xia, Xiaojun; Mai, Hai‐Qiang; Hu, Xueda; Zhang, Zemin; Zeng, Yi‐Xin; Bei, Jin‐Xin

doi:10.1038/s41467-021-21043-4

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Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution

Published in Nature Communications • Feb 2, 2021

Authors:

Yang Liu

Shuai He

Xiliang Wang

Abstract

Abstract The heterogeneous nature of tumour microenvironment (TME) underlying diverse treatment responses remains unclear in nasopharyngeal carcinoma (NPC). Here, we profile 176,447 cells from 10 NPC tumour-blood pairs, using single-cell transcriptome coupled with T cell receptor sequencing. Our ana...

Subject

CD8

Nasopharyngeal carcinoma

Immune system

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