The antigenic anatomy of SARS-CoV-2 receptor binding domain

Dejnirattisai, Wanwisa; Zhou, Daming; M. Ginn, Helen; M. E. Duyvesteyn, Helen; Supasa, Piyada; Brett Case, James; Zhao, Yuguang; S. Walter, Thomas; J. Mentzer, Alexander; Liu, Chang; Wang, Beibei; C. Paesen, Guido; Slon-Campos, Jose; López‐Camacho, César; M. Kafai, Natasha; L. Bailey, Adam; E. Chen, Rita; Ying, Baoling; Thompson, Craig; S. Bolton, Jai; Fyfe, Alex; Gupta, Sunetra; Kit Tan, Tiong; Gilbert‐Jaramillo, Javier; James, William; L. Knight, Michael; W. Carroll, Miles; Skelly, Donal; Dold, Christina; Peng, Yanchun; H. Levin, Robert; Dong, Tao; J. Pollard, Andrew; C. Knight, Julian; Klenerman, Paul; Temperton, Nigel; R. Hall, David; A. Williams, Mark; G. Paterson, Neil; Bertram, F.K.R.; Alistair Siebert, C.; K. Clare, Daniel; Howe, Andrew; Radecke, Julika; Song, Yun; Townsend, Alain; A. Huang, Kuan-Ying; E. Fry, Elizabeth; Mongkolsapaya, Juthathip; Diamond, Michael; Ren, Jingshan; I. Stuart, David; Screaton, Gavin

doi:10.1016/j.cell.2021.02.032

Public

The antigenic anatomy of SARS-CoV-2 receptor binding domain

Published in Cell • Feb 18, 2021

Authors:

Wanwisa Dejnirattisai

Daming Zhou

Helen M. Ginn

Abstract

Antibodies are crucial to immune protection against SARS-CoV-2, with some in emergency use as therapeutics. Here, we identify 377 human monoclonal antibodies (mAbs) recognizing the virus spike and focus mainly on 80 that bind the receptor binding domain (RBD). We devise a competition data-driven met...

Subject

Biology

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Virology

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