Losartan Improves Memory, Neurogenesis and Cell Motility in Transgenic Alzheimer’s Mice

Johannes Drews, Henning; Klein, Roman; Lourhmati, Ali; Buadze, Marine; Schaeffeler, Elke; Lang, Thomas; Seferyan, Torgom; R. Hanson, Leah; H. Frey, William; C.G.M. de Vries, Tom; A.E.W. Thijssen-van Loosdregt, Inge; H. Gleiter, Christoph; Schwab, Matthias; Danielyan, Lusine

doi:10.3390/ph14020166

Public

Losartan Improves Memory, Neurogenesis and Cell Motility in Transgenic Alzheimer’s Mice

Published in Pharmaceuticals • Feb 20, 2021

Authors:

Henning Johannes Drews

Roman Klein

Ali Lourhmati

Abstract

Angiotensin receptor blockers (ARBs) have demonstrated multiple neuroprotective benefits in Alzheimer’s disease (AD) models. However, their beneficial effects on memory deficits, cholinergic activity, neurogenesis and Amyloid beta (Aβ) clearance reveal significant interstudy variability. The deliver...

Subject

Losartan

Neurogenesis

Pharmacology

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